Impacts of dietary konjac glucomannan supplementation on growth, antioxidant capacity, hepatic lipid metabolism and inflammatory response in golden pompano (Trachinotus ovatus) fed a high fat diet

This study examined the effect of konjac glucomannan (KGM) supplementation in diets with different lipid levels on growth, antioxidant capacity, hepatic metabolism and inflammatory response juvenile pompano ( Trachinotus ovatus ). Triplicate groups fish (12.07 ± 0.21 g) were fed eight experimental containing two 9% (basal-fat diet, BFD) 18% (high-fat HFD), four KGM (0, 0.5, 1 2%) for 60 days. Pompano HFD exhibited markedly lower growth feed efficiency than BFD, supplementation, particularly at 1% inclusion, significantly improved performance both BFD HFD. In addition, showed higher whole-body protein contents BFD. Irrespective dietary level, whole body, dorsal ventral muscle reduced by up to while opposite was found body content. Dietary also HSI, liver contents, as well droplets liver. Supplementation serum total cholesterol, triglyceride, low-density lipoprotein cholesterol free fatty acids levels. Furthermore, irrespective increasing enhanced IgM lysozyme alkaline phosphatase activities, alanine aminotransferase aspartate activities. increased superoxide dismutase catalase decreased malondialdehyde concentration glutathione peroxidase, activities concentrations capacity peroxidase activity expression genes associated catabolism ppar? , cpt1 hsl ) transport fabp1 apoB100 cd36 ), anabolism related srebp1 ppar? fas acc Moreover, pro-inflammatory cytokines including tumor necrosis factor ? interleukin-8 down-regulated, anti-inflammatory cytokine transforming ?1 supplementation. conclusion, diet efficiency, responses pompano, can mitigate excessive deposition tissues farmed fish. • Konjac promoted anti-oxidation . Lipid through acids. The recommended level 1%.